InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZBTB16

Summary

InnateDB Gene

IDBG-630682.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB16

Gene Name

zinc finger and BTB domain-containing protein 16

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011266

Encoded Proteins

IDBP-682160

zinc finger and BTB domain-containing protein 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25705792

[Homo sapiens] MIR146A upregulation by CXCR4 antagonist AMD3100 treatment or ZBTB16 silencing, decreases CXCR4 protein expression and prevents HIV-1 infection of leukemic monocytic cell line and CD4(+) T lymphocytes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109906:
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:24917133-25116350

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014968

ENSBTAP00000014968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001823	mesonephros development
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009952	anterior/posterior pattern specification
GO:0030097	hemopoiesis
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035116	embryonic hindlimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0045600	positive regulation of fat cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045778	positive regulation of ossification
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0051138	positive regulation of NK T cell differentiation
GO:0051216	cartilage development
GO:0061036	positive regulation of cartilage development