InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FCER1A

Summary

InnateDB Gene

IDBG-630768.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCER1A

Gene Name

high affinity immunoglobulin epsilon receptor subunit alpha precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012887

Encoded Proteins

IDBP-682247

high affinity immunoglobulin epsilon receptor subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179639:
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:10539988-10546195

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017127

ENSBTAP00000017127

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019767	IgE receptor activity
GO:0019863	IgE binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001812	positive regulation of type I hypersensitivity
GO:0001820	serotonin secretion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0019370	leukotriene biosynthetic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045401	positive regulation of interleukin-3 biosynthetic process
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling