Version 5.4
Bos taurus Gene: DLG5
Summary
InnateDB Gene IDBG-630788.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLG5
Gene Name disks large homolog 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013187
Encoded Proteins
IDBP-682353
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151208:
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:33719674-33842951
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017554 ENSBTAP00000017554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0030859 polarized epithelial cell differentiation
GO:0030901 midbrain development
GO:0042981 regulation of apoptotic process
GO:0045176 apical protein localization
GO:0045186 zonula adherens assembly
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0071896 protein localization to adherens junction
GO:0072205 metanephric collecting duct development
Cellular Component
GO:0005622 intracellular
GO:0005913 cell-cell adherens junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151208
View Gene Order
ENSMUSG00000021782
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.109079 Bt.11856
RefSeq NM_001206088
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca