Version 5.4
Bos taurus Gene: KIRREL
Summary
InnateDB Gene IDBG-631028.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIRREL
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005799
Encoded Proteins
IDBP-682568
kin of IRRE like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183853:
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12308303-12326076
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007626 ENSBTAP00000007626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017022 myosin binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0007588 excretion
GO:0016337 single organismal cell-cell adhesion
GO:0030838 positive regulation of actin filament polymerization
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0043198 dendritic shaft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000183853
View Gene Order
ENSMUSG00000041734
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_257032
Nephrin interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
Cross-References
SwissProt
TrEMBL F1N3G9
UniProt Splice Variant
Entrez Gene 781667
UniGene Bt.66793
RefSeq XM_003585822
HUGO HGNC:15734
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007054
GenPept
RNA Seq Atlas 781667

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca