Version 5.4
Bos taurus Gene: P2RX2
Summary
InnateDB Gene IDBG-631034.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX2
Gene Name P2X purinoceptor 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007496
Encoded Proteins
IDBP-682527
purinergic receptor P2X, ligand-gated ion channel, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187848:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45573970-45577518
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009869 ENSBTAP00000009869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007268 synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0007605 sensory perception of sound
GO:0009743 response to carbohydrate
GO:0010033 response to organic substance
GO:0014832 urinary bladder smooth muscle contraction
GO:0030432 peristalsis
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0048266 behavioral response to pain
GO:0048741 skeletal muscle fiber development
GO:0050909 sensory perception of taste
GO:0051260 protein homooligomerization
Cellular Component
GO:0005622 intracellular
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187848
View Gene Order
ENSMUSG00000029503
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BIH1
UniProt Splice Variant
Entrez Gene 527499
UniGene Bt.25388
RefSeq NM_001192643
HUGO HGNC:15459
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02044946
GenPept
RNA Seq Atlas 527499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca