InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.65952

Summary

InnateDB Gene

IDBG-631087.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.65952

Gene Name

E3 ubiquitin-protein ligase RNF135

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017225

Encoded Proteins

IDBP-682581

RING finger protein 135

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23950712

[Homo sapiens] RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181481:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18330388-18343193

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022890

ENSBTAP00000022890

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding