InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NRG3

Summary

InnateDB Gene

IDBG-631178.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRG3

Gene Name

pro-neuregulin-3, membrane-bound isoform

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009587

Encoded Proteins

IDBP-682686

neuregulin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185737:
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:38301492-38351092

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012609

ENSBTAP00000012609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007389	pattern specification process
GO:0009790	embryo development
GO:0030879	mammary gland development
GO:0035556	intracellular signal transduction
GO:0060596	mammary placode formation