Version 5.4
| Bos taurus Gene: CD36 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-631266.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | CD36 | ||||||
| Gene Name | Platelet glycoprotein 4 | ||||||
| Synonyms | GPIIIB; GPIV; PAS-4 | ||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000017866 | ||||||
| Encoded Proteins |
Platelet glycoprotein 4
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| InnateDB Annotation from Orthologs | |||||||
| Summary |
[Homo sapiens] CD36 mediates host defence against Cryptococcus neoformans and Candida albicans through cytokine production.
[Homo sapiens] CD36 ectodomain binds negatively charged diacylglycerol ligands and CD36, along with CD14, has a non-redundant role for loading ligands onto TLR2 in the plasma-membrane.
[Homo sapiens] CD36 is a selective and non-redundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer.
[Homo sapiens] CD36-TLR4-TLR6 activation is a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation.
[Mus musculus] MSR1 and Cd36 share several ligands and are involved in largely overlapping physiological and pathological processes, but they differ significantly in their effects on proinflammatory and immunoregulatory functions of macrophages.
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| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135218:
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 4:40581484-40643369 | ||||||
| Strand | Reverse strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
Platelet degranulation pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Activated TLR4 signalling pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Class I MHC mediated antigen processing & presentation pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transcriptional regulation of white adipocyte differentiation pathway
Toll-Like Receptors Cascades pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
PPARA activates gene expression pathway
Innate Immune System pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Antigen processing-Cross presentation pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Scavenging by Class B Receptors pathway
Developmental Biology pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
PPARA activates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Scavenging by Class B Receptors pathway
Immune System pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
Metabolism pathway
Hemostasis pathway
Platelet degranulation pathway
Transcriptional regulation of white adipocyte differentiation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Hemostasis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Toll-Like Receptors Cascades pathway
Antigen processing-Cross presentation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Adaptive Immune System pathway
PPARA activates gene expression pathway
Developmental Biology pathway
Activated TLR4 signalling pathway
Response to elevated platelet cytosolic Ca2+ pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Scavenging by Class B Receptors pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Hematopoietic cell lineage pathway
ECM-receptor interaction pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Malaria pathway
Fat digestion and absorption pathway
Phagosome pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Malaria pathway
Phagosome pathway
Fat digestion and absorption pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | |||||||
| UniGene | Bt.43948 | ||||||
| RefSeq | NM_001278621 NM_174010 XM_005205320 XM_005205321 XM_005205322 XM_005205323 XM_005205324 XM_005205325 XM_005205326 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | |||||||
| GenPept | |||||||
| RNA Seq Atlas | |||||||