Bos taurus Gene: ARHGEF6 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-631282.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | ARHGEF6 | ||||||||||
Gene Name | rho guanine nucleotide exchange factor 6 | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000017850 | ||||||||||
Encoded Proteins |
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129675:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome X:20273538-20389008 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH |
TCR pathway
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REACTOME |
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
Cell-extracellular matrix interactions pathway
Signalling by NGF pathway
Cell-Cell communication pathway
Cell junction organization pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Cell-extracellular matrix interactions pathway
Signalling by NGF pathway
Signal Transduction pathway
Cell junction organization pathway
p75 NTR receptor-mediated signalling pathway
Cell-Cell communication pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Pancreatic cancer pathway
Regulation of actin cytoskeleton pathway
Pancreatic cancer pathway
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INOH |
Integrin signaling pathway pathway
PDGF signaling pathway pathway
Integrin signaling pathway pathway
PDGF signaling pathway pathway
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PID NCI |
Regulation of RAC1 activity
Integrin-linked kinase signaling
CDC42 signaling events
Regulation of CDC42 activity
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Bt.103399 | ||||||||||
RefSeq | NM_001193000 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||