Version 5.4
Bos taurus Gene: MOGS
Summary
InnateDB Gene IDBG-631312.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOGS
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001844
Encoded Proteins
IDBP-682831
mannosyl-oligosaccharide glucosidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115275:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10149024-10151887
Strand Forward strand
Band
Transcripts
ENSBTAT00000002408 ENSBTAP00000002408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004573 mannosyl-oligosaccharide glucosidase activity
Biological Process
GO:0009311 oligosaccharide metabolic process
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115275
View Gene Order
ENSMUSG00000030036
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_198618
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu00510
N-Glycan biosynthesis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B7U1
UniProt Splice Variant
Entrez Gene 516155
UniGene
RefSeq XM_003582764 XM_003586619
HUGO HGNC:24862
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030324
GenPept
RNA Seq Atlas 516155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca