InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DCTN1

Summary

InnateDB Gene

IDBG-631341.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN1

Gene Name

dynactin subunit 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004887

Encoded Proteins

IDBP-682877

dynactin subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204843:
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:10235834-10253077

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006430

ENSBTAP00000006430

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0045502	dynein binding
GO:0048037	cofactor binding

Biological Process

GO:0010970	microtubule-based transport
GO:0032402	melanosome transport

Cellular Component

GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005813	centrosome
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0031252	cell leading edge
GO:0043234	protein complex