InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PFDN5

Summary

InnateDB Gene

IDBG-631350.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFDN5

Gene Name

Prefoldin subunit 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008935

Encoded Proteins

IDBP-682874

Prefoldin subunit 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123349:
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:26886091-26890186

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011762

ENSBTAP00000011762

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051086	chaperone mediated protein folding independent of cofactor
GO:0060041	retina development in camera-type eye
GO:0090090	negative regulation of canonical Wnt signaling pathway