Version 5.4
Bos taurus Gene: PD-L1
Summary
InnateDB Gene IDBG-631351.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PD-L1
Gene Name programmed cell death 1 ligand 1 precursor
Synonyms PD-L1
Species Bos taurus
Ensembl Gene ENSBTAG00000000095
Encoded Proteins
IDBP-682875
programmed cell death 1 ligand 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21097698
[Homo sapiens] CD274 expression in macrophages is induced upon exposure to HIV virions and TLR stimulation. In addition, IL10 also up-regulates CD274 expression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120217:
Gene Information
Type Protein coding
Genomic Location Chromosome 8:39497223-39514616
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008067 ENSBTAP00000008067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0031295 T cell costimulation
GO:0042130 negative regulation of T cell proliferation
GO:2001181 positive regulation of interleukin-10 secretion
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120217
View Gene Order
ENSMUSG00000016496
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19324
PD-1 signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_263643
PD-1 signaling pathway
REACT_230745
Immune System pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C5NU11
UniProt Splice Variant
Entrez Gene 533834
UniGene Bt.101480
RefSeq NM_001163412 XM_005209964
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB510902 DAAA02022688
GenPept BAH82662
RNA Seq Atlas 533834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca