Version 5.4
Bos taurus Gene: BT.63558
Summary
InnateDB Gene IDBG-631359.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.63558
Gene Name LIM domain-binding protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018707
Encoded Proteins
IDBP-682961
LIM domain binding 3
IDBP-682966
LIM domain binding 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122367:
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:41657195-41713873
Strand Forward strand
Band
Transcripts
ENSBTAT00000065403 ENSBTAP00000056431
ENSBTAT00000024904 ENSBTAP00000024904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0045214 sarcomere organization
Cellular Component
GO:0005856 cytoskeleton
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000122367
View Gene Order
ENSMUSG00000021798
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.63558
RefSeq NM_001035416
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca