InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.22873

Summary

InnateDB Gene

IDBG-631386.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.22873

Gene Name

Tyrosine-protein kinase receptor

Synonyms

TRKA

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003060

Encoded Proteins

IDBP-682955

Tyrosine-protein kinase receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198400:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:14019444-14037555

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003980

ENSBTAP00000003980

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0010465	nerve growth factor receptor activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007623	circadian rhythm
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030183	B cell differentiation
GO:0032320	positive regulation of Ras GTPase activity
GO:0042490	mechanoreceptor differentiation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045766	positive regulation of angiogenesis
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048485	sympathetic nervous system development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060385	axonogenesis involved in innervation
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex