Version 5.4
Bos taurus Gene: TNFAIP1
Summary
InnateDB Gene IDBG-631555.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP1
Gene Name BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008115
Encoded Proteins
IDBP-683100
tumor necrosis factor, alpha-induced protein 1 (endothelial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109079:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:20379926-20388607
Strand Forward strand
Band
Transcripts
ENSBTAT00000010671 ENSBTAP00000010671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0006955 immune response
GO:0009790 embryo development
GO:0016477 cell migration
GO:0035024 negative regulation of Rho protein signal transduction
GO:0043149 stress fiber assembly
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109079
View Gene Order
ENSMUSG00000017615
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.29035
RefSeq NM_001192290 XM_005220113 XM_005220114 XM_005220115
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca