Version 5.4
| Bos taurus Gene: CD47 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-631689.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | CD47 | ||||||||||||||
| Gene Name | leukocyte surface antigen CD47 precursor | ||||||||||||||
| Synonyms | IAP | ||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000003585 | ||||||||||||||
| Encoded Proteins |
leukocyte surface antigen CD47 precursor
leukocyte surface antigen CD47 precursor
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||
| Summary |
[Mus musculus] Cd47 plays a protective role against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.
[Mus musculus] Cd47 plays a role as a negative regulator in inducing protective immune responses to influenza vaccination.
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| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196776:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 1:53103996-53169038 | ||||||||||||||
| Strand | Reverse strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Extracellular matrix organization pathway
Hemostasis pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Extracellular matrix organization pathway
Signal regulatory protein (SIRP) family interactions pathway
Integrin cell surface interactions pathway
Cell-Cell communication pathway
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| KEGG |
ECM-receptor interaction pathway
ECM-receptor interaction pathway
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| INOH | |||||||||||||||
| PID NCI |
Beta3 integrin cell surface interactions
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| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | Bt.87076 | ||||||||||||||
| RefSeq | NM_174708 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | |||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||