Version 5.4
Bos taurus Gene: FOXO3
Summary
InnateDB Gene IDBG-631758.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXO3
Gene Name forkhead box protein O3
Synonyms FOXO-3
Species Bos taurus
Ensembl Gene ENSBTAG00000011234
Encoded Proteins
IDBP-683314
forkhead box O3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19050264
[Homo sapiens] FOXO3 is a transcriptional activator which targets genes FAS ligand and TNFSF10 (TRAIL), involved in the extrinsic apoptotic pathway, and BBC3 (PUMA), PMAIP1 (Noxa), and BCL2L11 (Bim), which are part of the intrinsic apoptotic pathway.
PMID 20739833
[Homo sapiens] FOXO3, along with AKT, is involved in TLR9-mediated anti-apoptosis and is a distinct regulator for FLICE-like inhibitory protein (FLIP) expression.
PMID 22531926
[Homo sapiens] FOXO3 is an IKBKE-controlled checkpoint of IRF activation and regulation of IFNB expression.
PMID 22982991
[Homo sapiens] OXO3 is a negative regulator of IRF7 transcription, and forms a coherent feed-forward regulatory circuit with IRF7 and IFNB to maximize antiviral responses. (Demonstrated in mice)
PMID 22531926
[Mus musculus] Foxo3 is an Ikbke-controlled checkpoint of IRF activation and regulation of Ifnb expression. (Demonstrated in human)
PMID 22982991
[Mus musculus] FOXO3 is a negative regulator of Irf7 transcription, and forms a coherent feed-forward regulatory circuit with Irf7 and Ifnb to maximize antiviral responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118689:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:42008606-42118673
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014920 ENSBTAP00000014920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001542 ovulation from ovarian follicle
GO:0001544 initiation of primordial ovarian follicle growth
GO:0001547 antral ovarian follicle growth
GO:0001556 oocyte maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006417 regulation of translation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0034599 cellular response to oxidative stress
GO:0042593 glucose homeostasis
GO:0043525 positive regulation of neuron apoptotic process
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000118689
View Gene Order
ENSMUSG00000048756
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12442
AKT phosphorylates targets in the nucleus pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_111057
Signaling by NODAL pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_220645
Signaling by NODAL pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_218211
AKT phosphorylates targets in the nucleus pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05213
Endometrial cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
mmu05213
Endometrial cancer pathway
mmu05223
Non-small cell lung cancer pathway
mmu04062
Chemokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
Insulin receptor signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
pi3kcipathway
Class I PI3K signaling events
myc_represspathway
Validated targets of C-MYC transcriptional repression
foxopathway
FoxO family signaling
p73pathway
p73 transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
il2_pi3kpathway
IL2 signaling events mediated by PI3K
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL F1N4K5
UniProt Splice Variant
Entrez Gene 535530
UniGene Bt.44365
RefSeq NM_001206083 XM_005210804 XM_005210805 XM_005210806
HUGO HGNC:3821
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02025936 DAAA02025937 DAAA02025938 DAAA02025939 DAAA02025940 DAAA02025941 DAAA02025942
GenPept
RNA Seq Atlas 535530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca