Version 5.4
Bos taurus Gene: RPGRIP1L
Summary
InnateDB Gene IDBG-631868.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPGRIP1L
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012499
Encoded Proteins
IDBP-683456
RPGRIP1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103494:
The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:22021983-22114274
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016585 ENSBTAP00000016585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031870 thromboxane A2 receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001889 liver development
GO:0007163 establishment or maintenance of cell polarity
GO:0007368 determination of left/right symmetry
GO:0007420 brain development
GO:0008589 regulation of smoothened signaling pathway
GO:0021532 neural tube patterning
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021670 lateral ventricle development
GO:0021772 olfactory bulb development
GO:0022038 corpus callosum development
GO:0035108 limb morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042384 cilium assembly
GO:0043010 camera-type eye development
GO:0043584 nose development
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0060039 pericardium development
GO:0060271 cilium morphogenesis
GO:0060322 head development
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005911 cell-cell junction
GO:0005929 cilium
GO:0005930 axoneme
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000103494
View Gene Order
ENSMUSG00000033282
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BJB4
UniProt Splice Variant
Entrez Gene 518659
UniGene
RefSeq XM_002694781 XM_005195228 XM_005218802 XM_596855
HUGO HGNC:29168
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046444
GenPept
RNA Seq Atlas 518659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca