InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPAST

Summary

InnateDB Gene

IDBG-631955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPAST

Gene Name

Spastin

Synonyms

SPG4

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021694

Encoded Proteins

IDBP-683546

Spastin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000021574:
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:14714304-14769808

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046919

ENSBTAP00000044166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007049	cell cycle
GO:0007109	cytokinesis, completion of separation
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0008152	metabolic process
GO:0030154	cell differentiation
GO:0031117	positive regulation of microtubule depolymerization
GO:0034214	protein hexamerization
GO:0051013	microtubule severing
GO:0051260	protein homooligomerization
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030496	midbody
GO:0031410	cytoplasmic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000021574

View Gene Order

ENSMUSG00000024068

View Gene Order

Cross-References

SwissProt

A2VDN5

TrEMBL

UniProt Splice Variant

Entrez Gene

521442

UniGene

Bt.46123

RefSeq

NM_001081591 XM_005212529

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133327

GenPept

AAI33328

RNA Seq Atlas

521442