InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PVRL1

Summary

InnateDB Gene

IDBG-631966.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVRL1

Gene Name

poliovirus receptor-related protein 1 precursor

Synonyms

HVEC; prr1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015939

Encoded Proteins

IDBP-683554

poliovirus receptor-related 1 (herpesvirus entry mediator C)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110400:
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:30743667-30758246

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061522

ENSBTAP00000053311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002089	lens morphogenesis in camera-type eye
GO:0002934	desmosome organization
GO:0006826	iron ion transport
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0048593	camera-type eye morphogenesis
GO:0060041	retina development in camera-type eye
GO:0070166	enamel mineralization