InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GRIK2

Summary

InnateDB Gene

IDBG-631973.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK2

Gene Name

glutamate receptor, ionotropic kainate 2

Synonyms

GRIK5

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033153

Encoded Proteins

IDBP-683555

glutamate receptor, ionotropic, kainate 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164418:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:48476204-49218551

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015563

ENSBTAP00000015563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005216	ion channel activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043524	negative regulation of neuron apoptotic process
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0050806	positive regulation of synaptic transmission
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane