InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EDNRB

Summary

InnateDB Gene

IDBG-631994.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDNRB

Gene Name

Endothelin B receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005299

Encoded Proteins

IDBP-683580

Endothelin B receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136160:
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:53310604-53407024

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006979

ENSBTAP00000006979

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0006885	regulation of pH
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007422	peripheral nervous system development
GO:0007497	posterior midgut development
GO:0008217	regulation of blood pressure
GO:0014043	negative regulation of neuron maturation
GO:0014826	vein smooth muscle contraction
GO:0030318	melanocyte differentiation
GO:0032269	negative regulation of cellular protein metabolic process
GO:0035645	enteric smooth muscle cell differentiation
GO:0042310	vasoconstriction
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048246	macrophage chemotaxis
GO:0048484	enteric nervous system development