Bos taurus Gene: KIFAP3 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-632045.2 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | KIFAP3 | ||||||||||||||||
Gene Name | kinesin-associated protein 3 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000017727 | ||||||||||||||||
Encoded Proteins |
kinesin-associated protein 3
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075945:
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 \'Armadillo\' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 16:38360035-38502334 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
MHC class II antigen presentation pathway
Kinesins pathway
Factors involved in megakaryocyte development and platelet production pathway
Translocation of GLUT4 to the plasma membrane pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
Membrane Trafficking pathway
Hemostasis pathway
Membrane Trafficking pathway
Immune System pathway
Kinesins pathway
Factors involved in megakaryocyte development and platelet production pathway
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Translocation of GLUT4 to the plasma membrane pathway
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KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | Q3MHI2 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 518402 | ||||||||||||||||
UniGene | Bt.24896 | ||||||||||||||||
RefSeq | NM_001035329 XM_005216900 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC105229 DAAA02042857 | ||||||||||||||||
GenPept | AAI05230 | ||||||||||||||||
RNA Seq Atlas | 518402 | ||||||||||||||||