InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RASGRP3

Summary

InnateDB Gene

IDBG-632283.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP3

Gene Name

ras guanyl-releasing protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008006

Encoded Proteins

IDBP-683895

ras guanyl-releasing protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152689:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:16087064-16134216

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046852

ENSBTAP00000044100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0017016	Ras GTPase binding
GO:0019900	kinase binding
GO:0046582	Rap GTPase activator activity
GO:0046872	metal ion binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction