Bos taurus Gene: TNFRSF1B | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-632369.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | TNFRSF1B | ||||||||||||||||
Gene Name | tumor necrosis factor receptor superfamily member 1B precursor | ||||||||||||||||
Synonyms | TNF-RII/TNFRSF1B | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000024928 | ||||||||||||||||
Encoded Proteins |
tumor necrosis factor receptor superfamily member 1B
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] TNFRSF1B signalling induces selective BIRC2-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signalling.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000028137:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 16:42376258-42409768 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME | |||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
Adipocytokine signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Cytokine-cytokine receptor interaction pathway
Adipocytokine signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
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INOH | |||||||||||||||||
PID NCI |
TNF receptor signaling pathway
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | O18915 Q3MHI9 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 338033 | ||||||||||||||||
UniGene | Bt.67402 | ||||||||||||||||
RefSeq | NM_001040490 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AF031589 BC105222 DAAA02042944 DAAA02042945 | ||||||||||||||||
GenPept | AAB84301 AAI05223 | ||||||||||||||||
RNA Seq Atlas | 338033 | ||||||||||||||||