InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RACGAP1

Summary

InnateDB Gene

IDBG-632426.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RACGAP1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012784

Encoded Proteins

IDBP-684062

Rac GTPase activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161800:
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:30042571-30059413

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016988

ENSBTAP00000016988

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0043014	alpha-tubulin binding
GO:0043015	gamma-tubulin binding
GO:0046872	metal ion binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0000915	cytokinesis, actomyosin contractile ring assembly
GO:0007108	cytokinesis, initiation of separation
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007405	neuroblast proliferation
GO:0008272	sulfate transport
GO:0009790	embryo development
GO:0032467	positive regulation of cytokinesis
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0051256	spindle midzone assembly involved in mitosis
GO:0051988	regulation of attachment of spindle microtubules to kinetochore

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032154	cleavage furrow
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex