Homo sapiens Gene: FOLR1
Summary
InnateDB Gene IDBG-63244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOLR1
Gene Name folate receptor 1 (adult)
Synonyms FBP; FOLR;
Species Homo sapiens
Ensembl Gene ENSG00000110195
Encoded Proteins
folate receptor 1 (adult)
folate receptor 1 (adult)
folate receptor 1 (adult)
folate receptor 1 (adult)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72189558-72196301
Strand Forward strand
Band q13.4
Transcripts
ENST00000312293 ENSP00000308137
ENST00000393681 ENSP00000377286
ENST00000393679 ENSP00000377284
ENST00000393676 ENSP00000377281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005542 folic acid binding
GO:0008517 folic acid transporter activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0008219 cell death
GO:0015884 folic acid transport
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031362 anchored component of external side of plasma membrane
GO:0031526 brush border membrane
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600451 Hs.73769
RefSeq NM_000802 NM_016724 NM_016725 NM_016729
HUGO
OMIM
CCDS CCDS8211
HPRD 00638
IMGT
EMBL
GenPept
RNA Seq Atlas