InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DRD3

Summary

InnateDB Gene

IDBG-632626.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD3

Gene Name

D(3) dopamine receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002132

Encoded Proteins

IDBP-684258

dopamine receptor D3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151577:
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:59297291-59344117

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002768

ENSBTAP00000002768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding

Biological Process

GO:0001975	response to amphetamine
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002031	G-protein coupled receptor internalization
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007626	locomotory behavior
GO:0008542	visual learning
GO:0014059	regulation of dopamine secretion
GO:0019216	regulation of lipid metabolic process
GO:0030814	regulation of cAMP metabolic process
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0034776	response to histamine
GO:0040014	regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0043278	response to morphine
GO:0045471	response to ethanol
GO:0045776	negative regulation of blood pressure
GO:0048148	behavioral response to cocaine
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0051898	negative regulation of protein kinase B signaling
GO:0060134	prepulse inhibition
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0060161	positive regulation of dopamine receptor signaling pathway