Bos taurus Gene: DHH | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-632665.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | DHH | ||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000000124 | ||||||||||||||||||
Encoded Proteins |
Uncharacterized protein
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139549:
This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 5:30894556-30899509 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH |
Hedgehog pathway
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REACTOME |
Class B/2 (Secretin family receptors) pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Release of Hh-Np from the secreting cell pathway
Signaling by GPCR pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
GPCR ligand binding pathway
Disease pathway
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KEGG |
Hedgehog signaling pathway pathway
Hedgehog signaling pathway pathway
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INOH |
GPCR signaling pathway
Hedgehog signaling pathway pathway
GPCR signaling pathway
Hedgehog signaling pathway pathway
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PID NCI |
Signaling events mediated by the Hedgehog family
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E2IU41 F1MFP2 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 525833 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | XM_001788869 XM_002687306 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | DAAA02012950 HM622070 | ||||||||||||||||||
GenPept | ADN43395 | ||||||||||||||||||
RNA Seq Atlas | 525833 | ||||||||||||||||||