InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MLL2

Summary

InnateDB Gene

IDBG-632681.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLL2

Gene Name

Uncharacterized protein

Synonyms

MLL2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014429

Encoded Proteins

IDBP-684368

myeloid/lymphoid or mixed-lineage leukemia 2

IDBP-684371

myeloid/lymphoid or mixed-lineage leukemia 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167548:
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:30931917-30964080

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019193	ENSBTAP00000019193
ENSBTAT00000063707	ENSBTAP00000054949

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0032259	methylation
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0043627	response to estrogen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter