InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SNAPIN

Summary

InnateDB Gene

IDBG-632741.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAPIN

Gene Name

SNARE-associated protein Snapin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012470

Encoded Proteins

IDBP-684379

SNARE-associated protein Snapin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143553:
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:16783420-16785104

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016548

ENSBTAP00000016548

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0008089	anterograde axon cargo transport
GO:0010977	negative regulation of neuron projection development
GO:0016079	synaptic vesicle exocytosis
GO:0016188	synaptic vesicle maturation
GO:0031629	synaptic vesicle fusion to presynaptic membrane
GO:0043393	regulation of protein binding
GO:0048489	synaptic vesicle transport
GO:0048490	anterograde synaptic vesicle transport
GO:0072553	terminal button organization

Cellular Component

GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0031083	BLOC-1 complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm