InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MET

Summary

InnateDB Gene

IDBG-632820.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MET

Gene Name

Hepatocyte growth factor receptor

Synonyms

c-met; HGFR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006161

Encoded Proteins

IDBP-684485

hepatocyte growth factor receptor precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105976:
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:51912652-52042198

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008102

ENSBTAP00000008102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005008	hepatocyte growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001889	liver development
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0010828	positive regulation of glucose transport
GO:0014812	muscle cell migration
GO:0014902	myotube differentiation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030534	adult behavior
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis