InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49331

Summary

InnateDB Gene

IDBG-632847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49331

Gene Name

transitional endoplasmic reticulum ATPase

Synonyms

p97

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015000

Encoded Proteins

IDBP-684519

transitional endoplasmic reticulum ATPase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165280:
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:59732258-59746989

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019970

ENSBTAP00000019970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 442 interaction(s) predicted by orthology.

Predicted by orthology
Total	442 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0031593	polyubiquitin binding
GO:0035800	deubiquitinase activator activity
GO:0044822	poly(A) RNA binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019985	translesion synthesis
GO:0030970	retrograde protein transport, ER to cytosol
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0070842	aggresome assembly
GO:1903006	positive regulation of protein K63-linked deubiquitination
GO:1903007	positive regulation of Lys63-specific deubiquitinase activity

Cellular Component

GO:0000502	proteasome complex
GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0035861	site of double-strand break
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome