InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PFKM

Summary

InnateDB Gene

IDBG-632886.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKM

Gene Name

6-phosphofructokinase, muscle type

Synonyms

ATP-PFK; PFK-M

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000286

Encoded Proteins

IDBP-684562

6-phosphofructokinase, muscle type

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152556:
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:32312957-32337525

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000359

ENSBTAP00000000359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008443	phosphofructokinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0070061	fructose binding

Biological Process

GO:0006002	fructose 6-phosphate metabolic process
GO:0006096	glycolytic process
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0032024	positive regulation of insulin secretion
GO:0042593	glucose homeostasis
GO:0046716	muscle cell cellular homeostasis
GO:0046835	carbohydrate phosphorylation
GO:0051259	protein oligomerization

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005945	6-phosphofructokinase complex
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0097228	sperm principal piece