Version 5.4
Bos taurus Gene: ORAI1
Summary
InnateDB Gene IDBG-632961.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORAI1
Gene Name calcium release-activated calcium channel protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004457
Encoded Proteins
IDBP-684623
calcium release-activated calcium channel protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21239714
[Homo sapiens] ORAI1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.
PMID 21239714
[Mus musculus] Orai1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:55858843-55873788
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005840 ENSBTAP00000005840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
Biological Process
GO:0002115 store-operated calcium entry
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000049686
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_215282
Platelet calcium homeostasis pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
REACT_227667
Elevation of cytosolic Ca2+ levels pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A5PKA7
UniProt Splice Variant
Entrez Gene 517688
UniGene Bt.28728
RefSeq NM_001099002 XM_005217843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142419 DAAA02045269
GenPept AAI42420
RNA Seq Atlas 517688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca