Version 5.4
Bos taurus Gene: LAMA2
Summary
InnateDB Gene IDBG-632972.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMA2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010229
Encoded Proteins
IDBP-684734
laminin, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196569:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:68129102-68665593
Strand Forward strand
Band
Transcripts
ENSBTAT00000061257 ENSBTAP00000053179
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0045995 regulation of embryonic development
Cellular Component
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0042383 sarcolemma
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000196569
View Gene Order
ENSMUSG00000019899
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_206066
Extracellular matrix organization pathway
REACT_202342
Laminin interactions pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
hsa05146
Amoebiasis pathway
hsa05145
Toxoplasmosis pathway
mmu04512
ECM-receptor interaction pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05416
Viral myocarditis pathway
mmu05146
Amoebiasis pathway
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin4_pathway
Alpha6 beta4 integrin-ligand interactions
Cross-References
SwissProt
TrEMBL F1MMT2
UniProt Splice Variant
Entrez Gene 101910012
UniGene Bt.18332
RefSeq XM_001787958 XM_002690220 XM_003585167 XM_003585378 XM_005197755 XM_005199408
HUGO HGNC:6482
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02026593 DAAA02026594 DAAA02026595 DAAA02026596 DAAA02026597 DAAA02026598 DAAA02026599 DAAA02026600 DAAA02026601 DAAA02026602 DAAA02026603 DAAA02026604 DAAA02026605 DAAA02026606 DAAA02026607
GenPept
RNA Seq Atlas 100138434 100848461 101904210 101910012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca