InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6AP1

Summary

InnateDB Gene

IDBG-632976.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6AP1

Gene Name

V-type proton ATPase subunit S1

Synonyms

Ac45; ATP6IP1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012117

Encoded Proteins

IDBP-684643

V-type proton ATPase subunit S1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071553:
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008]
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40402701-40410481

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016073

ENSBTAP00000016073

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045851	pH reduction
GO:0045921	positive regulation of exocytosis
GO:0051656	establishment of organelle localization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005773	vacuole
GO:0005774	vacuolar membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0070062	extracellular vesicular exosome