InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RNF34

Summary

InnateDB Gene

IDBG-633010.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF34

Gene Name

E3 ubiquitin-protein ligase RNF34

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002315

Encoded Proteins

IDBP-684673

E3 ubiquitin-protein ligase RNF34

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170633:
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56021830-56042534

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002986

ENSBTAP00000002986

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis