Version 5.4
| Bos taurus Gene: TK2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-633052.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TK2 | ||||||||
| Gene Name | Uncharacterized protein | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000005152 | ||||||||
| Encoded Proteins |
thymidine kinase 2, mitochondrial
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166548:
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 18:34368485-34393020 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Pyrimidine salvage reactions pathway
Metabolism of nucleotides pathway
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
Cell Cycle pathway
Pyrimidine metabolism pathway
Cell Cycle, Mitotic pathway
Metabolism pathway
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| KEGG |
Pyrimidine metabolism pathway
Drug metabolism pathway
Pyrimidine metabolism pathway
Drug metabolism pathway
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| INOH |
Pyrimidine nucleotides nucleosides metabolism pathway
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| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MNI9 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 615457 | ||||||||
| UniGene | |||||||||
| RefSeq | XM_005195237 XM_005195239 XM_005218824 XM_005218826 | ||||||||
| HUGO | HGNC:11831 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02046673 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 615457 | ||||||||