InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VPS29

Summary

InnateDB Gene

IDBG-633135.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS29

Gene Name

Vacuolar protein sorting-associated protein 29

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008417

Encoded Proteins

IDBP-684820

Vacuolar protein sorting-associated protein 29

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111237:
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56617708-56622846

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011076

ENSBTAP00000011076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004647	phosphoserine phosphatase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016311	dephosphorylation
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030904	retromer complex
GO:0043231	intracellular membrane-bounded organelle