Version 5.4
Bos taurus Gene: TLN1
Summary
InnateDB Gene IDBG-633137.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLN1
Gene Name talin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025868
Encoded Proteins
IDBP-685094
talin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137076:
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:60281244-60312068
Strand Reverse strand
Band
Transcripts
ENSBTAT00000036631 ENSBTAP00000036487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0017166 vinculin binding
GO:0030274 LIM domain binding
GO:0051015 actin filament binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0030866 cortical actin cytoskeleton organization
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137076
View Gene Order
ENSMUSG00000028465
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_17015
Metabolism of proteins pathway
REACT_17044
Muscle contraction pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_246154
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_224553
Hemostasis pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_262759
Muscle contraction pathway
REACT_261444
Axon guidance pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_188576
Developmental Biology pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_263034
Semaphorin interactions pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
hsa04510
Focal adhesion pathway
mmu04510
Focal adhesion pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
rhoa_pathway
RhoA signaling pathway
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL F1MDH3
UniProt Splice Variant
Entrez Gene 783470
UniGene Bt.64581
RefSeq NM_001205428 XM_005210127
HUGO HGNC:11845
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023131
GenPept
RNA Seq Atlas 783470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca