InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNXB

Summary

InnateDB Gene

IDBG-633174.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNXB

Gene Name

tenascin-X precursor

Synonyms

TNX

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001444

Encoded Proteins

IDBP-684893

tenascin-X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168477:
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5\' and 3\' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:27085415-27136954

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001893

ENSBTAP00000001893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007160	cell-matrix adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0032963	collagen metabolic process
GO:0043206	extracellular fibril organization
GO:0043506	regulation of JUN kinase activity
GO:0048251	elastic fiber assembly

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005583	fibrillar collagen trimer
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome