Version 5.4
| Bos taurus Gene: TNFAIP8L2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-633196.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TNFAIP8L2 | ||||||||
| Gene Name | Tumor necrosis factor alpha-induced protein 8-like protein 2 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000020394 | ||||||||
| Encoded Proteins |
Tumor necrosis factor alpha-induced protein 8-like protein 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] TNFAIP8L2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis by binding to CASP8 and inhibiting nuclear factor kappa B activation while promoting apoptosis.
[Homo sapiens] TNFAIP8L2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway. (Demonstrated in mouse)
[Homo sapiens] TNFAIP8L2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection. (Demonstrated in mice)
[Mus musculus] Tnfaip8l2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway.
[Mus musculus] Tnfaip8l2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163154:
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 3:19695881-19698696 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.49405 | ||||||||
| RefSeq | NM_001034389 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||