Version 5.4
| Bos taurus Gene: ARG1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-633227.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | ARG1 | ||||||||||
| Gene Name | Arginase-1 | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000012403 | ||||||||||
| Encoded Proteins |
Arginase-1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] ARG1 expression induced by intracellular pathogens in mouse classically activated macrophages (CAMs) through the TLR pathway, suppressing nitric oxide production and thwarting effective immunity independent of the STAT6 pathway.
[Homo sapiens] PI3K/PTEN-regulated extracellular ARG1 acts as a paracrine regulator of inflammation and immunity. Demonstrated in mice.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118520:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 9:70499608-70516610 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Metabolism of amino acids and derivatives pathway
Urea cycle pathway
Metabolism pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism pathway
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
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| KEGG |
Arginine and proline metabolism pathway
Amoebiasis pathway
Arginine and proline metabolism pathway
Amoebiasis pathway
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| INOH |
Arginine Proline metabolism pathway
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| PID NCI |
ATF-2 transcription factor network
IL4-mediated signaling events
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| Cross-References | |||||||||||
| SwissProt | Q2KJ64 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 513608 | ||||||||||
| UniGene | Bt.97117 | ||||||||||
| RefSeq | NM_001046154 XM_005210924 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC105497 | ||||||||||
| GenPept | AAI05498 | ||||||||||
| RNA Seq Atlas | 513608 | ||||||||||