Version 5.4
Bos taurus Gene: UBE4B
Summary
InnateDB Gene IDBG-633294.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE4B
Gene Name ubiquitin conjugation factor E4 B
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010401
Encoded Proteins
IDBP-685000
ubiquitin conjugation factor E4 B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130939:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:44263938-44385466
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013729 ENSBTAP00000013729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0019899 enzyme binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130939
View Gene Order
ENSMUSG00000028960
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL A6QNS2
UniProt Splice Variant
Entrez Gene 520833
UniGene Bt.17976
RefSeq NM_001102504
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148970 DAAA02042992
GenPept AAI48971
RNA Seq Atlas 520833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca