Version 5.4
Homo sapiens Gene: CDK2AP1
Summary
InnateDB Gene IDBG-63337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK2AP1
Gene Name cyclin-dependent kinase 2 associated protein 1
Synonyms doc-1; DOC1; DORC1; p12DOC-1; ST19
Species Homo sapiens
Ensembl Gene ENSG00000111328
Encoded Proteins
IDBP-63339
cyclin-dependent kinase 2 associated protein 1
IDBP-602715
cyclin-dependent kinase 2 associated protein 1
IDBP-594604
cyclin-dependent kinase 2 associated protein 1
IDBP-602179
cyclin-dependent kinase 2 associated protein 1
IDBP-587725
cyclin-dependent kinase 2 associated protein 1
IDBP-590170
cyclin-dependent kinase 2 associated protein 1
IDBP-809533
cyclin-dependent kinase 2 associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:123260971-123272334
Strand Reverse strand
Band q24.31
Transcripts
ENST00000261692 ENSP00000261692
ENST00000538446 ENSP00000442502
ENST00000535979 ENSP00000442565
ENST00000542174 ENSP00000440729
ENST00000544658 ENSP00000438561
ENST00000535796 ENSP00000444499
ENST00000618072 ENSP00000479982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0000084 mitotic S phase
GO:0006261 DNA-dependent DNA replication
GO:0006468 protein phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029394
View Gene Order
ENSBTAG00000020504
Not yet available
Cross-References
SwissProt O14519
TrEMBL F5GZF0
UniProt Splice Variant
Entrez Gene 8099
UniGene Hs.740398
RefSeq NM_001270433 NM_001270434 NM_004642
HUGO HGNC:14002
OMIM 602198
CCDS CCDS58289 CCDS9245
HPRD 03726
IMGT
EMBL AB006077 AC068768 AF006484 BC034717 DB465022
GenPept AAC77831 AAH34717 BAA22937
RNA Seq Atlas 8099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca