Version 5.4
Bos taurus Gene: ATXN3
Summary
InnateDB Gene IDBG-633604.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATXN3
Gene Name ataxin-3
Synonyms ataxin-3
Species Bos taurus
Ensembl Gene ENSBTAG00000005786
Encoded Proteins
IDBP-685391
ataxin-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066427:
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:57347865-57381142
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007611 ENSBTAP00000007611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 misfolded or incompletely synthesized protein catabolic process
GO:0010810 regulation of cell-substrate adhesion
GO:0034605 cellular response to heat
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035640 exploration behavior
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0071218 cellular response to misfolded protein
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
GO:0042405 nuclear inclusion body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000066427
View Gene Order
ENSMUSG00000021189
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6H799 F1N3H4
UniProt Splice Variant
Entrez Gene 790880
UniGene Bt.108445
RefSeq NM_001099216
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146166 DAAA02053007
GenPept AAI46167
RNA Seq Atlas 790880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca