Homo sapiens Gene: DCAF7
Summary
InnateDB Gene IDBG-63365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF7
Gene Name DDB1 and CUL4 associated factor 7
Synonyms AN11; HAN11; SWAN-1; WDR68;
Species Homo sapiens
Ensembl Gene ENSG00000136485
Encoded Proteins
DDB1 and CUL4 associated factor 7
DDB1 and CUL4 associated factor 7
DDB1 and CUL4 associated factor 7
DDB1 and CUL4 associated factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signalling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63550461-63594266
Strand Forward strand
Band q23.3
Transcripts
ENST00000415273 ENSP00000403920
ENST00000431926 ENSP00000402312
ENST00000580091
ENST00000582274
ENST00000614556 ENSP00000483236
ENST00000615512 ENSP00000480250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0043234 protein complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005828
HUGO
OMIM
CCDS CCDS74127
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas