InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EHMT2

Summary

InnateDB Gene

IDBG-633713.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHMT2

Gene Name

histone-lysine N-methyltransferase EHMT2

Synonyms

BAT8

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005676

Encoded Proteins

IDBP-685524

euchromatic histone-lysine N-methyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22412156

[Homo sapiens] EHMT2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of EHMT2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses. (Demonstrated in mice)

PMID 22412156

[Mus musculus] Ehmt2 catalyzes di-methylation of histone H3 at the promoter of interferon (IFN) and IFN-inducible antiviral genes as an epigenetic silencing mechanism in fibroblasts. Ablation of Ehmt2 results in phenotypic conversion to potent IFN-producing cells and renders resistance to RNA viruses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204371:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq, Jul 2008]
This gene is located in a gene cluster within the human major histocompatibility complex class III region on chromosome 6. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but recent publications show that there is only a single gene at this locus. The encoded protein is a histone methyltransferase, which may be involved in repression of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:27277900-27291344

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007456

ENSBTAP00000007456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0046976	histone methyltransferase activity (H3-K27 specific)
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006275	regulation of DNA replication
GO:0006306	DNA methylation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007130	synaptonemal complex assembly
GO:0007281	germ cell development
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0016571	histone methylation
GO:0032259	methylation
GO:0034968	histone lysine methylation
GO:0035265	organ growth
GO:0051567	histone H3-K9 methylation
GO:0070734	histone H3-K27 methylation